Very late activation antigens (VLA) are human leukocyte-neuronal crossreactive cell surface antigens.

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Very late activation antigens (VLA) are human leukocyte-neuronal crossreactive cell surface antigens

The antigenic relationship between human neuronal and lymphocyte cell surface antigens has been analyzed using heteroantisera raised against human peripheral blood mononuclear cells (PBMC). The specificities of the crossreactive antigens were examined by immunoprecipitation of 125I-labeled SK-N-SH cultured neuronal cells using rabbit anti-PBMC (RAPBMC) sera and compared to known specificities u...

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The specificity of transplantation immunity and T cell cytotoxicity against leukemias induced by RadLV was examined. Subcutaneous inoculation of two RadLV leukemias induced in BALB/c mice, BALBRVB and BALBRVD, resulted in initial tumor growth in CB6F1 mice, followed by complete tumor regression. Mice that had rejected leukemias BALBRVB or BALBRVD were subsequently challenged with various tumors...

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Cell Surface Antigens of Human Renal Cancer

The two key questions of h u m a n cancer immunology remain unresolved. These relate to whether tumor-specific antigens exist in h u m a n cancer and, if so, whether there is immunological recognition of these antigens in humans. To date, candidate h u m a n tumor-specific antigens defined by heterologous sera have, on further analysis, turned out to belong to the category of differentiation an...

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Monoclonal antibodies to human cell surface antigens.

Many of the leukocyte cell surface molecules are known by "CD" numbers. In this Appendix, a short introduction describes the history and the use of CD nomenclature and provides a few key references to enable access to the wider literature. This is followed by a table that lists all human molecules with approved CD names, tabulating alternative names, key structural features, cellular expression...

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Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins

Cytokines are known to be important regulators of normal hemopoiesis, acting in concert with components of the bone marrow microenvironment. Interactions with this microenvironment are known to regulate the proliferation, differentiation, and homing of hemopoietic progenitor (CD34+) cells. Adhesive interactions with the extracellular matrix retain CD34+ cells in close proximity to cytokines, bu...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1986

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.164.2.393